Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music.
Identifieur interne : 000117 ( Main/Exploration ); précédent : 000116; suivant : 000118Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music.
Auteurs : Clara E. James [Suisse] ; Eckart Altenmüller [Allemagne] ; Matthias Kliegel [Suisse] ; Tillmann H C. Krüger [Allemagne] ; Dimitri Van De Ville [Suisse] ; Florian Worschech [Allemagne] ; Laura Abdili [Suisse] ; Daniel S. Scholz [Allemagne] ; Kristin Jünemann [Allemagne] ; Alexandra Hering [Suisse] ; Frédéric Grouiller [Suisse] ; Christopher Sinke [Allemagne] ; Damien Marie [Suisse]Source :
- BMC geriatrics [ 1471-2318 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
English descriptors
- KwdEn :
- MESH :
- geographic : Germany, Switzerland.
- diagnostic imaging : Brain.
- Aged, Cognition, Humans, Music, Neuronal Plasticity.
Abstract
BACKGROUND
Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that stimulate neuroplasticity and delay or reverse symptoms of cognitive and cerebral decline. To be successful, these regimens should be easily integrated in daily life and intrinsically motivating. This study combines for the first-time protocolled music practice in elderly with cutting-edge neuroimaging and behavioral approaches, comparing two types of musical education.
METHODS
We conduct a two-site Hannover-Geneva randomized intervention study in altogether 155 retired healthy elderly (64-78) years, (63 in Geneva, 92 in Hannover), offering either piano instruction (experimental group) or musical listening awareness (control group). Over 12 months all participants receive weekly training for 1 hour, and exercise at home for ~ 30 min daily. Both groups study different music styles. Participants are tested at 4 time points (0, 6, and 12 months & post-training (18 months)) on cognitive and perceptual-motor aptitudes as well as via wide-ranging functional and structural neuroimaging and blood sampling.
DISCUSSION
We aim to demonstrate positive transfer effects for faculties traditionally described to decline with age, particularly in the piano group: executive functions, working memory, processing speed, abstract thinking and fine motor skills. Benefits in both groups may show for verbal memory, hearing in noise and subjective well-being. In association with these behavioral benefits we anticipate functional and structural brain plasticity in temporal (medial and lateral), prefrontal and parietal areas and the basal ganglia. We intend exhibiting for the first time that musical activities can provoke important societal impacts by diminishing cognitive and perceptual-motor decline supported by functional and structural brain plasticity.
TRIAL REGISTRATION
The Ethikkomission of the Leibniz Universität Hannover approved the protocol on 14.08.17 (no. 3604-2017), the neuroimaging part and blood sampling was approved by the Hannover Medical School on 07.03.18. The full protocol was approved by the Commission cantonale d'éthique de la recherche de Genève (no. 2016-02224) on 27.02.18 and registered at clinicaltrials.gov on 17.09.18 ( NCT03674931 , no. 81185).
DOI: 10.1186/s12877-020-01761-y
PubMed: 33087078
PubMed Central: PMC7576734
Affiliations:
- Allemagne, Suisse
- Basse-Saxe, Canton de Genève, Canton de Vaud
- Genève, Hanovre, Lausanne
- Université de Genève
Links toward previous steps (curation, corpus...)
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James</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland. clara.james@hesge.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland. clara.james@hesge.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Kliegel, Matthias" sort="Kliegel, Matthias" uniqKey="Kliegel M" first="Matthias" last="Kliegel">Matthias Kliegel</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Kruger, Tillmann H C" sort="Kruger, Tillmann H C" uniqKey="Kruger T" first="Tillmann H C" last="Krüger">Tillmann H C. Krüger</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Van De Ville, Dimitri" sort="Van De Ville, Dimitri" uniqKey="Van De Ville D" first="Dimitri" last="Van De Ville">Dimitri Van De Ville</name><affiliation wicri:level="3"><nlm:affiliation>Swiss Federal Institute of Technology Lausanne (EPFL), Route Cantonale, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Federal Institute of Technology Lausanne (EPFL), Route Cantonale, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medecine of the University of Geneva, Switzerland, Campus Biotech, Chemin des Mines 9, 1211, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medecine of the University of Geneva, Switzerland, Campus Biotech, Chemin des Mines 9, 1211, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Worschech, Florian" sort="Worschech, Florian" uniqKey="Worschech F" first="Florian" last="Worschech">Florian Worschech</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Abdili, Laura" sort="Abdili, Laura" uniqKey="Abdili L" first="Laura" last="Abdili">Laura Abdili</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Scholz, Daniel S" sort="Scholz, Daniel S" uniqKey="Scholz D" first="Daniel S" last="Scholz">Daniel S. Scholz</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Junemann, Kristin" sort="Junemann, Kristin" uniqKey="Junemann K" first="Kristin" last="Jünemann">Kristin Jünemann</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Hering, Alexandra" sort="Hering, Alexandra" uniqKey="Hering A" first="Alexandra" last="Hering">Alexandra Hering</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Grouiller, Frederic" sort="Grouiller, Frederic" uniqKey="Grouiller F" first="Frédéric" last="Grouiller">Frédéric Grouiller</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Center for Affective Sciences, University of Geneva, 1205 Geneva, Switzerland. Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Center for Affective Sciences, University of Geneva, 1205 Geneva, Switzerland. Campus Biotech, Chemin des Mines 9, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Sinke, Christopher" sort="Sinke, Christopher" uniqKey="Sinke C" first="Christopher" last="Sinke">Christopher Sinke</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Marie, Damien" sort="Marie, Damien" uniqKey="Marie D" first="Damien" last="Marie">Damien Marie</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33087078</idno><idno type="pmid">33087078</idno><idno type="doi">10.1186/s12877-020-01761-y</idno><idno type="pmc">PMC7576734</idno><idno type="wicri:Area/Main/Corpus">000134</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000134</idno><idno type="wicri:Area/Main/Curation">000134</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000134</idno><idno type="wicri:Area/Main/Exploration">000134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music.</title><author><name sortKey="James, Clara E" sort="James, Clara E" uniqKey="James C" first="Clara E" last="James">Clara E. James</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland. clara.james@hesge.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland. clara.james@hesge.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Kliegel, Matthias" sort="Kliegel, Matthias" uniqKey="Kliegel M" first="Matthias" last="Kliegel">Matthias Kliegel</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Kruger, Tillmann H C" sort="Kruger, Tillmann H C" uniqKey="Kruger T" first="Tillmann H C" last="Krüger">Tillmann H C. Krüger</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Van De Ville, Dimitri" sort="Van De Ville, Dimitri" uniqKey="Van De Ville D" first="Dimitri" last="Van De Ville">Dimitri Van De Ville</name><affiliation wicri:level="3"><nlm:affiliation>Swiss Federal Institute of Technology Lausanne (EPFL), Route Cantonale, 1015, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Federal Institute of Technology Lausanne (EPFL), Route Cantonale, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medecine of the University of Geneva, Switzerland, Campus Biotech, Chemin des Mines 9, 1211, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Medecine of the University of Geneva, Switzerland, Campus Biotech, Chemin des Mines 9, 1211, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Worschech, Florian" sort="Worschech, Florian" uniqKey="Worschech F" first="Florian" last="Worschech">Florian Worschech</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Abdili, Laura" sort="Abdili, Laura" uniqKey="Abdili L" first="Laura" last="Abdili">Laura Abdili</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Scholz, Daniel S" sort="Scholz, Daniel S" uniqKey="Scholz D" first="Daniel S" last="Scholz">Daniel S. Scholz</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Junemann, Kristin" sort="Junemann, Kristin" uniqKey="Junemann K" first="Kristin" last="Jünemann">Kristin Jünemann</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Hering, Alexandra" sort="Hering, Alexandra" uniqKey="Hering A" first="Alexandra" last="Hering">Alexandra Hering</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Grouiller, Frederic" sort="Grouiller, Frederic" uniqKey="Grouiller F" first="Frédéric" last="Grouiller">Frédéric Grouiller</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Center for Affective Sciences, University of Geneva, 1205 Geneva, Switzerland. Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Center for Affective Sciences, University of Geneva, 1205 Geneva, Switzerland. Campus Biotech, Chemin des Mines 9, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Sinke, Christopher" sort="Sinke, Christopher" uniqKey="Sinke C" first="Christopher" last="Sinke">Christopher Sinke</name><affiliation wicri:level="3"><nlm:affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Marie, Damien" sort="Marie, Damien" uniqKey="Marie D" first="Damien" last="Marie">Damien Marie</name><affiliation wicri:level="1"><nlm:affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC geriatrics</title><idno type="eISSN">1471-2318</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Brain (diagnostic imaging)</term><term>Cognition (MeSH)</term><term>Germany (MeSH)</term><term>Humans (MeSH)</term><term>Music (MeSH)</term><term>Neuronal Plasticity (MeSH)</term><term>Switzerland (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (MeSH)</term><term>Cognition (MeSH)</term><term>Encéphale (imagerie diagnostique)</term><term>Humains (MeSH)</term><term>Musique (MeSH)</term><term>Plasticité neuronale (MeSH)</term><term>Suisse (MeSH)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term><term>Switzerland</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cognition</term><term>Humans</term><term>Music</term><term>Neuronal Plasticity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allemagne</term><term>Cognition</term><term>Humains</term><term>Musique</term><term>Plasticité neuronale</term><term>Suisse</term><term>Sujet âgé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term><term>Suisse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that stimulate neuroplasticity and delay or reverse symptoms of cognitive and cerebral decline. To be successful, these regimens should be easily integrated in daily life and intrinsically motivating. This study combines for the first-time protocolled music practice in elderly with cutting-edge neuroimaging and behavioral approaches, comparing two types of musical education.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conduct a two-site Hannover-Geneva randomized intervention study in altogether 155 retired healthy elderly (64-78) years, (63 in Geneva, 92 in Hannover), offering either piano instruction (experimental group) or musical listening awareness (control group). Over 12 months all participants receive weekly training for 1 hour, and exercise at home for ~ 30 min daily. Both groups study different music styles. Participants are tested at 4 time points (0, 6, and 12 months & post-training (18 months)) on cognitive and perceptual-motor aptitudes as well as via wide-ranging functional and structural neuroimaging and blood sampling.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>We aim to demonstrate positive transfer effects for faculties traditionally described to decline with age, particularly in the piano group: executive functions, working memory, processing speed, abstract thinking and fine motor skills. Benefits in both groups may show for verbal memory, hearing in noise and subjective well-being. In association with these behavioral benefits we anticipate functional and structural brain plasticity in temporal (medial and lateral), prefrontal and parietal areas and the basal ganglia. We intend exhibiting for the first time that musical activities can provoke important societal impacts by diminishing cognitive and perceptual-motor decline supported by functional and structural brain plasticity.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>The Ethikkomission of the Leibniz Universität Hannover approved the protocol on 14.08.17 (no. 3604-2017), the neuroimaging part and blood sampling was approved by the Hannover Medical School on 07.03.18. The full protocol was approved by the Commission cantonale d'éthique de la recherche de Genève (no. 2016-02224) on 27.02.18 and registered at clinicaltrials.gov on 17.09.18 ( NCT03674931 , no. 81185).</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">33087078</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>21</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2318</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>10</Month><Day>21</Day></PubDate></JournalIssue><Title>BMC geriatrics</Title><ISOAbbreviation>BMC Geriatr</ISOAbbreviation></Journal><ArticleTitle>Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music.</ArticleTitle><Pagination><MedlinePgn>418</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12877-020-01761-y</ELocationID><Abstract><AbstractText Label="BACKGROUND">Recent data suggest that musical practice prevents age-related cognitive decline. But experimental evidence remains sparse and no concise information on the neurophysiological bases exists, although cognitive decline represents a major impediment to healthy aging. A challenge in the field of aging is developing training regimens that stimulate neuroplasticity and delay or reverse symptoms of cognitive and cerebral decline. To be successful, these regimens should be easily integrated in daily life and intrinsically motivating. This study combines for the first-time protocolled music practice in elderly with cutting-edge neuroimaging and behavioral approaches, comparing two types of musical education.</AbstractText><AbstractText Label="METHODS">We conduct a two-site Hannover-Geneva randomized intervention study in altogether 155 retired healthy elderly (64-78) years, (63 in Geneva, 92 in Hannover), offering either piano instruction (experimental group) or musical listening awareness (control group). Over 12 months all participants receive weekly training for 1 hour, and exercise at home for ~ 30 min daily. Both groups study different music styles. Participants are tested at 4 time points (0, 6, and 12 months & post-training (18 months)) on cognitive and perceptual-motor aptitudes as well as via wide-ranging functional and structural neuroimaging and blood sampling.</AbstractText><AbstractText Label="DISCUSSION">We aim to demonstrate positive transfer effects for faculties traditionally described to decline with age, particularly in the piano group: executive functions, working memory, processing speed, abstract thinking and fine motor skills. Benefits in both groups may show for verbal memory, hearing in noise and subjective well-being. In association with these behavioral benefits we anticipate functional and structural brain plasticity in temporal (medial and lateral), prefrontal and parietal areas and the basal ganglia. We intend exhibiting for the first time that musical activities can provoke important societal impacts by diminishing cognitive and perceptual-motor decline supported by functional and structural brain plasticity.</AbstractText><AbstractText Label="TRIAL REGISTRATION">The Ethikkomission of the Leibniz Universität Hannover approved the protocol on 14.08.17 (no. 3604-2017), the neuroimaging part and blood sampling was approved by the Hannover Medical School on 07.03.18. The full protocol was approved by the Commission cantonale d'éthique de la recherche de Genève (no. 2016-02224) on 27.02.18 and registered at clinicaltrials.gov on 17.09.18 ( NCT03674931 , no. 81185).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>James</LastName><ForeName>Clara E</ForeName><Initials>CE</Initials><Identifier Source="ORCID">0000-0001-7480-0682</Identifier><AffiliationInfo><Affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland. clara.james@hesge.ch.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland. clara.james@hesge.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Altenmüller</LastName><ForeName>Eckart</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kliegel</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krüger</LastName><ForeName>Tillmann H C</ForeName><Initials>THC</Initials><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van De Ville</LastName><ForeName>Dimitri</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Swiss Federal Institute of Technology Lausanne (EPFL), Route Cantonale, 1015, Lausanne, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medecine of the University of Geneva, Switzerland, Campus Biotech, Chemin des Mines 9, 1211, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Worschech</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdili</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scholz</LastName><ForeName>Daniel S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Institute for Music Physiology and Musicians' Medecine, Hannover University of Music, Drama and Media, Neues Haus 1, 30175, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jünemann</LastName><ForeName>Kristin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hering</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont-d'Arve 40, 1205, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Switzerland, Boulevard du Pont d'Arve 28, 1205, Genève, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grouiller</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Swiss Center for Affective Sciences, University of Geneva, 1205 Geneva, Switzerland. Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sinke</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center for Systems Neuroscience, Bünteweg 2, 30559, Hannover, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Social Psychiatry and Psychotherapy, Section of Clinical Psychology & Sexual Medicine, Hannover Medical School, Centre of Mental Health, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marie</LastName><ForeName>Damien</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Geneva School of Health Sciences, Geneva Musical Minds Lab (GEMMI Lab), University of Applied Sciences and Arts Western Switzerland HES-SO, Avenue de Champel 47, 1206, Geneva, 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Krüger</name><name sortKey="Kruger, Tillmann H C" sort="Kruger, Tillmann H C" uniqKey="Kruger T" first="Tillmann H C" last="Krüger">Tillmann H C. Krüger</name><name sortKey="Scholz, Daniel S" sort="Scholz, Daniel S" uniqKey="Scholz D" first="Daniel S" last="Scholz">Daniel S. Scholz</name><name sortKey="Scholz, Daniel S" sort="Scholz, Daniel S" uniqKey="Scholz D" first="Daniel S" last="Scholz">Daniel S. Scholz</name><name sortKey="Sinke, Christopher" sort="Sinke, Christopher" uniqKey="Sinke C" first="Christopher" last="Sinke">Christopher Sinke</name><name sortKey="Sinke, Christopher" sort="Sinke, Christopher" uniqKey="Sinke C" first="Christopher" last="Sinke">Christopher Sinke</name><name sortKey="Worschech, Florian" sort="Worschech, Florian" uniqKey="Worschech F" first="Florian" last="Worschech">Florian Worschech</name><name sortKey="Worschech, Florian" sort="Worschech, Florian" uniqKey="Worschech F" first="Florian" last="Worschech">Florian Worschech</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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